Experts Recommend Vitamin D 10,000 IU Upper Limit
The
tolerable upper intake level for oral vitamin D3 should be increased five-fold, experts from the US-based Council for Responsible
Nutrition (CRN) have said after a review of the science.
The risk assessment provides companies with a
guide for safe upper levels for product formulations, and consumers with vital information on safe dosage levels from products.
“This risk assessment was needed to show
that newer evidence supports the conclusion that vitamin D is much safer then previously thought, particularly because of
all the emergence research that shows benefit for vitamin D at higher levels than consumers were traditionally taking,”
lead author John Hathcock said.
Currently, the tolerable upper intake level (UL)
in Europe and the US is set at 2000 International Units (IU), equivalent to 50 micrograms per day. However, recent research,
particularly from clinical trials, suggests that this should be raised. The CRN scientists state that this could be raised
to 10,000 IU (250 micrograms per day).
The reviewers, from the CRN, Mount Sinai Hospital
in Toronto and Crieghton University in Nebraska, pooled data from 21 clinical trials using doses ranging from 10 to 2500 micrograms
(100,000 IU). The risk assessment also included data from animal studies, some of which used “extraordinarily high doses
of vitamin D3”.
“The lack of adverse effects in clinical
trials that used intake up to 1250 micrograms [50,000 IU] vitamin D per day and the lack of adverse effects at lower doses
inspires a high level of confidence in the data from the strongly designed clinical trials that used 250 micrograms [10,000
IU] vitamin D per day,” said the reviewers.
The researchers also note that for practically
all the reported cases of vitamin D toxicity have involved doses that were in excess of those studied in the clinical trials.
“Newer clinical trial data are sufficient to show that vitamin D is not toxic at intakes much higher than previously
considered unsafe,” said the reviewers.
Vitamin D is made by the body on exposure to
sunshine, or can be consumed in small amounts in milk, fish, liver and egg yolk. However because of the low amounts present
in the diet, and lack of sunshine in northern climates, with some estimates claiming that as much as 60 percent of northern
populations may be vitamin D deficient.
The reviewers note that normal dietary sources
provide about 2.5 micrograms per day, while this can be increased up to 10 micrograms with fortified foods. Dietary supplements
would provide higher doses.
“We applied the same method to our risk
assessment as the Food and Nutrition Board had used years ago, and our results concluded vitamin D could be safely taken in
much higher amounts,” Hathcock said.
Abstract
The objective of this review was
to apply the risk assessment methodology used by the Food and Nutrition Board (FNB) to derive a revised safe Tolerable Upper
Intake Level (UL) for vitamin D. New data continue to emerge regarding the health benefits of vitamin D beyond its role in
bone. The intakes associated with those benefits suggest a need for levels of supplementation, food fortification, or both
that are higher than current levels. A prevailing concern exists, however, regarding the potential for toxicity related to
excessive vitamin D intakes. The UL established by the FNB for vitamin D (50 µg, or 2000 IU) is not based on current evidence
and is viewed by many as being too restrictive, thus curtailing research, commercial development, and optimization of nutritional
policy. Human clinical trial data published subsequent to the establishment of the FNB vitamin D UL published in 1997 support
a significantly higher UL. We present a risk assessment based on relevant, well-designed human clinical trials of vitamin
D. Collectively, the absence of toxicity in trials conducted in healthy adults that used vitamin D dose 250 µg/d (10,000 IU
vitamin D3) supports the confident selection of this value as the UL.
Source
J.N. Hathcock, A. Shao, R. Vieth, R.
Heaney. Risk assessment for vitamin D. American Journal of Clinical Nutrition; January 2007, Volume 85, Pages 6-18.
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Co Q 10 is very important, especially if you
are on statins. However, there is one thing more to consider.
Your age determines what form of CoQ10 that your body can
absorb. Those under 50 can take ubiquinone with easy absorption. Those 50 and over need ubiquinol. I did a test myself and
am convinced!!!
Since I am 55, the ubiquinol far outperformed the ubiquinone. I believe both are invaluable, but age does
factor into the equation.
Read the following article................
Are you taking the wrong
type of CoQ10?
Coenzyme Q10 is one fantastic nutrient. Your
body typically makes plenty of it in your liver. But when your body doesn't make enough, it is hard to replace. That's because
CoQ10 isn't absorbed very well. Fortunately, there's one type of CoQ10 that's easily absorbed. And it can work wonders on
your heart.
Researchers recently gave a group of rabbits
one of three infusions: CoQ10 laden liposomes, empty liposomes, or saline. Then they closed off a coronary artery for 30 minutes
(occlusion). And then the researchers opened the artery to blood flow (reperfusion). The risk area to their main left ventricle
was 20% of its mass. It's well known and accepted that when a blood vessel occludes, its reopening can lead to yet more injury
called "reperfusion injury."
The rabbits that took the saline lost 70%
of the risk heart mass area. Those taking empty liposomes lost 60% of the risked area. But those given the CoQ10 lost only
30%. The authors concluded that CoQ10 greatly protected those heart muscle cells at the greatest risk.
CoQ10 is a critical nutrient for your cells'
furnaces, the mitochondria. And your heart, your body's constant workhorse, is loaded with mitochondria. CoQ10 is required
for them to make energy. It protects the mitochondria from the hot blast of combustion they stoke.
As I mentioned earlier, CoQ10 is tough to replenish
when your body doesn't make enough. So it's vital you take a CoQ10 that's easy to absorb. It is called ubiquinol. While it
is impractical to give you IV CoQ10, ubiquinol currently provides you the best delivery of CoQ10 available. If your heart
is at risk with any affliction, please be sure CoQ10 is at the top of your list.
